The main objective of this project is to develop a research network including private and public institutions focused on the exchange of expertise in imaging, genomics and bioinformatics to be utilized in monitoring therapies and disease progression in severe allergic asthma (AA).
The main scientific and technological objectives are:

• Development of novel optical imaging techniques and genomic biomarkers for severe AA
• Identification of potential biomarkers useful for clinical monitoring of therapeutic efficacy of novel compounds in the treatment of severe AA
• Development of novel high resolution imaging techniques in animal models of AA
• Bioinformatics support in the acquisition, management, archiving, and analysis of imaging and genomics data

P³AGI will investigate AA through an interdisciplinary approach which stems form the partners' complementary competences and instrumentation available; this will involve the following methodologies:

• Development of Novel Optical Imaging Procedures specific to AA
• Optical Imaging Methods in AA Models
• Monitoring severe allergic asthma in Hu-SCID mouse models of AA
• Genomics, bioinformatics, data and knowledge management

Given the complementarity of these steps, an intense scheme of staff secondments, training and networking activities and new recruitments has been planned in order to ensure that public and private partners share the best competences available for the joint achievement of P³AGI objective: a thorough understanding of AA and the exploration of its possible treatment.